Application Value of Radiomic Nomogram in the Differential Diagnosis of Prostate Cancer and Hyperplasia.

Objective: Prostate cancer and hyperplasia require different treatment strategies and have completely different outcomes; thus, preoperative identification of prostate cancer and hyperplasia is very important. The purpose of this study was to evaluate the application value of magnetic resonance imaging (MRI)-derived radiomic nomogram based on T2-weighted images (T2WI) in differentiating prostate cancer and hyperplasia. Materials and Methods: One hundred forty-six patients (66 cases of prostate cancer and 80 cases of prostate hyperplasia) who were confirmed by surgical pathology between September 2019 and September 2019 were selected. We manually delineated T2WI of all patients using ITK-SNAP software and radiomic analysis using Analysis Kit (AK) software. A total of 396 tumor texture features were extracted. Subsequently, the effective features were selected using the LASSO algorithm, and the radiomic feature model was constructed. Next, combined with independent clinical risk factors, a multivariate Logistic regression model was used to establish a radiomic nomogram. The receiver operator characteristic (ROC) curve was used to evaluate the prediction performance of the radiomic nomogram. Finally, the clinical application value of the nomogram was evaluated by decision curve analysis. Results: The PSA and the selected imaging features were significantly correlated with the differential diagnosis of prostate cancer and hyperplasia. The radiomic model had good discrimination efficiency for prostate cancer and hyperplasia. The training set (AUC = 0.85; 95% CI: 0.77-0.92) and testing set (AUC = 0.84; 95% CI: 0.72-0.96) were effective. The radiomic nomogram, combined with the radiomic characteristics of MRI and independent clinical risk factors, showed better differentiation efficiency in the training set (AUC = 0.91; 95% CI: 0.85-0.97) and testing set (AUC = 0.90; 95% CI: 0.81-0.99). The decision curve showed the clinical application value of the radiomic nomogram. Conclusion: The radiomic nomogram of T2-MRI combined with clinical risk factors can easily identify prostate cancer and hyperplasia. It also provides suggestions for further clinical events.

Diagnostic value of chest computed tomography images in adult Poland syndrome: a report of two cases.

Poland syndrome is a rare congenital developmental deformity characterized by unilateral agenesis or hypoplasia of thoracic wall soft tissue. We report two adult cases of Poland syndrome detected by computed tomography (CT) images. CT images of the two cases depicted an asymmetric chest wall with the absence of a breast and agenesis of the pectoralis muscles. A physical examination of case 1 showed a thin right chest wall with depression of the right nipple region. Hand deformities were also observed, including brachydactyly and syndactyly. In case 2, hand deformities were not found in a physical examination. Using multi-planar reconstruction, the size, position, origin, and termination of bilateral pectoral muscles could be compared symmetrically. For patients with Poland syndrome, a timely diagnosis and treatment are important. The use of chest CT in clinical practice could play an important role in the early diagnosis and treatment of Poland syndrome.

Machine Learning Analysis Reveals Abnormal Static and Dynamic Low-Frequency Oscillations Indicative of Long-Term Menstrual Pain in Primary Dysmenorrhea Patients.

BACKGROUND: Previous neuroimaging studies demonstrated that patients with primary dysmenorrhea (PD) exhibited dysfunctional resting-state brain activity. However, alterations of dynamic brain activity in PD patients have not been fully characterized. PURPOSE: Our study aimed to assess the effect of long-term menstrual pain on changes in static and dynamic neural activity in PD patients. MATERIAL AND METHODS: Twenty-eight PD patients and 28 healthy controls (HCs) underwent resting-state magnetic resonance imaging scans. The amplitude of low-frequency fluctuations (ALFF) and dynamic ALFF was used as classification features in a machine learning approach involving a support vector machine (SVM) classifier. RESULTS: Compared with the HC group, PD patients showed significantly increased ALFF values in the right cerebellum_crus2, right rectus, left supplementary motor area, right superior frontal gyrus, right supplementary motor area, and left superior frontal medial gyrus. Additionally, PD patients showed significantly decreased ALFF values in the right middle temporal gyrus and left thalamus. PD patients also showed significantly increased dALFF values in the right fusiform, Vermis_10, right middle temporal gyrus, right putamen, right insula, left thalamus, right precentral gyrus, and right postcentral gyrus. Based on ALFF and dALFF values, the SVM classifier achieved respective overall accuracies of 96.36% and 85.45% and respective areas under the curve of 1.0 and 0.95. CONCLUSION: PD patients demonstrated abnormal static and dynamic brain activities that involved the default mode network, sensorimotor network, and pain-related subcortical nuclei. Moreover, ALFF and dALFF may offer sensitive biomarkers for distinguishing patients with PD from HCs.

Malignant Peripheral Nerve Sheath Tumor of the Trigeminal Nerve Involving the Middle and Posterior Cranial Fossa.

BACKGROUND: Although benign trigeminal schwannomas are uncommon, malignant peripheral nerve sheath tumors (MPNSTs) of the trigeminal nerve are extraordinarily rare. CASE DESCRIPTION: A 56-year-old female presented with a 2-month-long history of numbness of the right face and progressive weakness of the left limbs. Preoperative neuroimages indicated a giant tumor involving the middle and posterior cranial fossa with similar radiologic characteristics to benign trigeminal schwannomas. However, histopathologic and immunochemical examinations confirmed the tumor to be an MPNST. A nearly gross total resection was obtained with a combined frontotemporal extradural and subtemporal anterior petrosal approach. The postoperative course was uneventful, and the patient received adjuvant radiotherapy subsequently. There was no recurrence of the tumor with a 6-month-long follow-up. CONCLUSION: MPNSTs of the trigeminal nerve are exceedingly rare. This study described the 21st case of MPNSTs of the trigeminal nerve. MPNSTs of the trigeminal nerve showed similar radiologic characteristics to benign trigeminal schwannomas, and accurate diagnosis depended on pathologic and immunochemical examinations. Gross total resection followed by radiotherapy is the usual treatment.